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Stay away from or Use Alternate Drug. Keep away from coadministration of delicate CYP3A4 substrates with ivosidenib or replace with different therapies. If coadministration is unavoidable, keep an eye on individuals for lack of therapeutic impact of those medication.
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Reserve concomitant prescribing of these medications in sufferers for whom other remedy choices are insufficient. Limit dosages and durations on the minimum necessary. Keep track of intently for indications of respiratory depression and sedation.
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